Klaas Nico Faber Selected Research

SYTOX Green

3/2015	Metformin protects primary rat hepatocytes against oxidative stress-induced apoptosis.
12/2013	Glutathione and antioxidant enzymes serve complementary roles in protecting activated hepatic stellate cells against hydrogen peroxide-induced cell death.
1/2013	Metformin protects rat hepatocytes against bile acid-induced apoptosis.
1/2012	Angiotensin II protects primary rat hepatocytes against bile salt-induced apoptosis.
1/2012	Pertussis toxin, an inhibitor of G(αi) PCR, inhibits bile acid- and cytokine-induced apoptosis in primary rat hepatocytes.
11/2010	Anti-oxidants do not prevent bile acid-induced cell death in rat hepatocytes.
11/2008	The active metabolite of leflunomide, A77 1726, protects rat hepatocytes against bile acid-induced apoptosis.
8/2008	Multidrug resistance-associated proteins are crucial for the viability of activated rat hepatic stellate cells.
4/2008	Carbon monoxide blocks oxidative stress-induced hepatocyte apoptosis via inhibition of the p54 JNK isoform.

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Klaas Nico Faber Research Topics

Disease

19	Inflammation (Inflammations) 03/2022 - 11/2004
13	Necrosis 01/2020 - 04/2008
12	Inflammatory Bowel Diseases (Inflammatory Bowel Disease) 12/2022 - 11/2004
11	Non-alcoholic Fatty Liver Disease 01/2022 - 01/2013
10	Liver Diseases (Liver Disease) 12/2017 - 04/2008
9	Ulcerative Colitis 12/2022 - 06/2007
9	Crohn Disease (Crohn's Disease) 03/2022 - 08/2009
9	Fibrosis (Cirrhosis) 01/2021 - 01/2017
7	Neoplasms (Cancer) 01/2022 - 12/2008
5	Liver Cirrhosis (Hepatic Cirrhosis) 01/2021 - 08/2008
5	Cholestasis 01/2020 - 11/2004
3	Colitis 12/2022 - 08/2009
3	Disease Progression 01/2022 - 02/2020
2	Hypoxia (Hypoxemia) 01/2022 - 01/2020
2	Acute Liver Failure (Fulminant Hepatic Failure) 11/2020 - 10/2016
2	Hepatocellular Carcinoma (Hepatoma) 01/2020 - 01/2012
2	Metabolic Syndrome (Dysmetabolic Syndrome X) 10/2019 - 01/2017
2	Type 2 Diabetes Mellitus (MODY) 10/2019 - 01/2013
2	Carcinoma (Carcinomatosis) 06/2007 - 11/2004
2	progressive familial intrahepatic 1 Cholestasis 01/2004 - 03/2002
1	Mitochondrial Diseases (Mitochondrial Disease) 02/2022
1	Muscular Diseases (Myopathy) 02/2022
1	Celiac Disease (Celiac Sprue) 01/2022
1	Fatty Liver 01/2022
1	Pathologic Constriction (Stenosis) 01/2022
1	Fistula 01/2022
1	Adenocarcinoma 01/2022
1	Iron Deficiencies 01/2022
1	Cytomegalovirus Infections (Inclusion Disease) 02/2020
1	Glycogen Storage Disease (Glycogenosis) 01/2020
1	Chronic Obstructive Pulmonary Disease (COPD) 01/2020
1	Idiopathic Pulmonary Fibrosis 01/2020
1	Infections 01/2020
1	Osteoporosis 01/2020

Drug/Important Bio-Agent (IBA)

12	Bile Acids and Salts (Bile Acids)IBA 01/2022 - 03/2002
9	SYTOX GreenIBA 03/2015 - 04/2008
8	Biomarkers (Surrogate Marker)IBA 02/2022 - 04/2007
7	Pharmaceutical PreparationsIBA 11/2020 - 01/2003
6	Proteins (Proteins, Gene)FDA Link 03/2022 - 04/2007
6	Vitamin A (Retinol)FDA LinkGeneric 01/2021 - 01/2009
6	CytokinesIBA 01/2018 - 11/2004
6	Acridine OrangeIBA 12/2013 - 08/2008
5	Caspase 3 (Caspase-3)IBA 01/2020 - 08/2008
4	C-Reactive ProteinIBA 01/2022 - 01/2017
4	Metformin (Glucophage)FDA LinkGeneric 11/2020 - 01/2013
4	Sulfhydryl Compounds (Thiols)IBA 06/2020 - 01/2019
3	Transcription Factors (Transcription Factor)IBA 01/2022 - 01/2017
3	Mixed Function Oxygenases (Monooxygenases)IBA 01/2022 - 01/2020
3	CollagenIBA 01/2022 - 01/2020
3	LipidsIBA 02/2021 - 12/2008
3	Glucose (Dextrose)FDA LinkGeneric 01/2020 - 02/2017
3	Leukocyte L1 Antigen Complex (Calgranulin)IBA 09/2019 - 01/2018
3	CaspasesIBA 03/2015 - 11/2008
3	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 01/2012 - 06/2007
2	sodium sulfate (sodium bisulfate)FDA LinkGeneric 12/2022 - 12/2008
2	Dextrans (Dextran)FDA Link 12/2022 - 12/2008
2	ProteomeIBA 03/2022 - 04/2007
2	Mitochondrial DNA (mtDNA)IBA 02/2022 - 01/2017
2	Reactive Oxygen Species (Oxygen Radicals)IBA 01/2022 - 11/2010
2	Retinol-Binding Proteins (Retinoid Binding Proteins)IBA 01/2021 - 10/2019
2	CholesterolIBA 01/2021 - 01/2017
2	Extracellular Matrix ProteinsIBA 01/2021 - 05/2017
2	Acetaminophen (Paracetamol)FDA LinkGeneric 11/2020 - 10/2016
2	Messenger RNA (mRNA)IBA 01/2020 - 06/2007
2	EnzymesIBA 01/2020 - 12/2013
2	Triglycerides (Triacylglycerol)IBA 10/2019 - 01/2017
2	oxidized low density lipoproteinIBA 10/2019 - 01/2017
2	AlbuminsIBA 09/2019 - 01/2017
2	Volatile Fatty AcidsIBA 01/2019 - 01/2019
2	Alanine Transaminase (SGPT)IBA 01/2017 - 01/2017
2	Poly(ADP-ribose) Polymerases (Poly ADP Ribose Polymerase)IBA 03/2015 - 04/2008
2	Hydrogen Peroxide (Hydroperoxide)FDA LinkGeneric 12/2013 - 07/2009
2	Heme (Haem)IBA 06/2013 - 11/2004
2	Member 11 Subfamily B ATP Binding Cassette TransporterIBA 11/2004 - 01/2004
1	GlucocorticoidsIBA 12/2022
1	S-Adenosylmethionine (Ademetionine)IBA 02/2022
1	Cytochromes b (Cytochrome b)IBA 02/2022
1	Mitochondrial Proteins (Mitochondrial Protein)IBA 02/2022
1	DNA (Deoxyribonucleic Acid)IBA 02/2022
1	Growth InhibitorsIBA 01/2022
1	Ferritins (Ferritin)IBA 01/2022
1	Immunoglobulin G (IgG)IBA 01/2022
1	Transferrin (beta 2 Transferrin)IBA 01/2022
1	IronIBA 01/2022
1	Nonesterified Fatty Acids (NEFA)IBA 02/2021
1	CarbohydratesIBA 01/2021
1	Cytoplasmic and Nuclear Receptors (Nuclear Receptors)IBA 01/2021
1	Ascorbic Acid (Vitamin C)FDA LinkGeneric 01/2021
1	BetacyaninsIBA 11/2020
1	Cysteine (L-Cysteine)FDA Link 11/2020
1	Riboflavin (Vitamin B2)FDA LinkGeneric 06/2020
1	vedolizumabIBA 02/2020
1	IntegrinsIBA 02/2020
1	pirfenidoneIBA 01/2020
1	Oxygen (Dioxygen)IBA 01/2020
1	Viral ProteinsIBA 01/2020
1	70-kDa Ribosomal Protein S6 Kinases (Ribosomal Protein S6 Kinases, 70 kDa)IBA 01/2020

Therapy/Procedure

4	Therapeutics 12/2022 - 08/2009
1	Chemoprevention 01/2022
1	Transplantation 02/2020